Heparin II domain of fibronectin mediates contractility through an α4β1 co-signaling pathway
نویسندگان
چکیده
Marie K. Schwinn, Jose M. Gonzalez Jr. , B'Ann T. Gabelt, Nader Sheibani, Paul L. Kaufman, Donna M. Peters⁎ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706, USA Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706, USA Department of Pharmacology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706, USA
منابع مشابه
Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.
PURPOSE To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling. METHODS The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, respectively, in differentiated human TM (HTM) cells. The role of ILK was dete...
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تاریخ انتشار 2010